May 11

Arrival and registration

20.30

Welcome words by organisers in the Lecture theatre

20.45

Welcome party in Marsala Room: cookies and Marsala
Posters to be put up.

Scientific programme

Each Lecturer will give a 30-min lecture/tutorial on background and methodology, followed by a 15 min discussion. They will then give a 35-min state-of-the-art lecture, followed by 10 min discussion.

May 12

Anion channels and transporters

Chair am:    Csanády        Chair pm:    Pusch

Moderator:    Stühmer

09.00

Michael Pusch: Small is beautiful - what can we learn from fluctuation analysis of (anion) channels and transporters?

10.30

Coffee break and posters

11.00

Alessio Accardi: Lipid transport mediated by a reconstituted TMEM16 ion channel.

12.30

Lunch

14.00

Raùl Estévez: Study of myelin genetic diseases allow identifying ClC-2 Cl^- channel function in glia.

15.30

Tea and posters

16.00

Chris Miller: Weird Ion ... weird ion channel

17.30

Discussion Group (30min) all speakers and moderator: the negative side of life

18.10

EMBO Women in Science lecture: Blanche Schwappach.
Juggling world-class science with life outside the lab: different paths for different people.

19.00

Dinner

20.30

Poster Session

May 13

Chair am:    Gadsby        Chair pm:    Kobertz

Moderator:    Miller



Transport and Trafficking

09.00

Robert Tampé: INs and OUTs of Adaptive Immunity – The ABC of Antigen Translocation and Virus Escape

10.30

Coffee break and posters

11.00

Blanche Schwappach: Trafficking mechanisms in the physiological regulation of ion channels

12.30

Lunch

Voltage-gated channels

14.00

Pancho Bezanilla: How voltage gates membrane proteins

15.30

Tea and posters

16.00

Eduardo Perozo (by Skype) Ion channel permeation.

17.30

Discussion Group (30min) all speakers and moderator: transport and trafficking

18.10

Data Blitz

19.10

Dinner

20.30

Poster Session

May 14

Glutamate channels/transporters (and cancer)

Chair am:    Tampé        Chair pm:    Liman

Moderator:    Nissen

09.00

Andrew Plested: Structure and mechanisms of Glutamate Receptor activation.

10.30

Coffee break and posters.

11.00

Michael Kavanaugh: Glutamate transporters.

12.30

Lunch

14.00

Olga Boudker (by Skype): Mechanism of a glutamate transporter homologue: from crystal structures to protein dynamics and energetics.

15.30

Tea and posters.

16.00

Walter Stühmer: Ion channels in cancer

17.30

Discussion group (30 min). All speakers and moderator: glutamate and disease.

18.10

EMBO Science and society lecture: Frances Ashcroft:
Communicating science to the general public.

19.00

Dinner

20.30

Poster Session.

May 15

Tools and Transporters

Chair am:    De Felice        Chair pm:    Forrest

Moderator:    Kavanaugh

09.00

Lucy Forrest: Using computational tools to understand secondary transport.

10.30

Coffee break

11.00

William Kobertz: Developing chemical tools to probe ion channel structure and function

12.30

Lunch

14.00

Baruch Kanner: Molecular Mechanism of Sodium-Coupled Neurotransmitter Transport 

15.30

Tea and posters.

16.00

Louis De Felice: Dopamine Transporters as Ion Channels: Methamphetamine, Cocaine, and Bath Salts.

17.30

Discussion group (30 min) all speakers and moderator: understanding transport.

18.10

Nanion: Live demonstrations on the Port-a-Patch and a lecture on the SURFE2R-technology will be given by Dr. Alessandreo Marabelli.

18.30

Dinner

20.30

Data Blitz.

21.30

Poster session

May 16

Channels and Disease

Chair am:    Accardi        Chair pm:    Plested

Moderator:    Bezanilla

09.00

Emily Liman: TRP ion channels in sensation: Sour taste transduction.       

10.30

Coffee break

11.00

Frances Ashcroft: ATP-sensitive potassium channels, diabetes and neurological disease.

12.00

Lunch

14.00

László Csanády: The molecular background of cystic fibrosis: Structure-function of CFTR, an ion channel evolved from an ABC transporter.

15.30

Tea and posters

16.00

David Gadsby: Mechanisms of function and dysfunction of the Na/K pump, a model P-type ATPase.

17.30

Discussion Group (30min) all speakers and moderator: from the lab bench to the clinic.

18.10

Poster session.

19.00

Dinner

20.30

EMBO LECTURE: Poul Nissen:
How do membrane transporters switch side?

May 17

End of Meeting: depart

SPONSORS

We thank FEBS, EMBO, CNR-DSFTM, Nanion, Ebsa and the Ettore Majorana Foundation and Centre for Scientific Culture for generously sponsoring this course.